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By Tiffany McMan | December 15th 2009 07:32 PM | 1 comment | Print | E-mail | Track Comments
This lays it out pretty clearly.  The tricky part is:
-  a genetic lack of dopamine receptors, inherited from one or both parents
-  leads to the brain continually feel starved for dopamine, on edge and can drive, sometimes  "sucessful", externalizing behavior
-  the dopamine starved brain overrides conscious control to drive external dopamine inducing behaviors: sex, eating, risky behavior, etc - think cutting to.  Guys brains act out, girls act in.
-  problem is can never get enough.  Externally triggered dopamine is very energy consuming and can't substitue for a systemic brain flaw, more behavior may raise need instead of soothe



Result - life gets very ugly.   Again, the addictive behavior is a symptom, NOT the problem/illness. 

What's often misleading about descriptions of addiction, and this video, is they talk about/show only the dopamine inducing result but don't explain the underlying brain deficits these poor folks are born with that causes the behavior.  

Moral weakness, lack of self-control, impulsiveness, personality problems, irresponsibility, bad people?   That's the easiest way to explain these tragic conditions.   Not medically valid, but our minds like easy answers of things we can't quickly understand.  Making things up works pretty well. 

Many illnesses used to be seen as moral weakness.  Wasn't the Black Death believed to be a god's judgment against sin?   

If I was suffocating from an acute lung disorder, I'd be doing some wild things and running around.  Somehow when it's the brain, we dislike the idea it can be sick like any other organ.

That's not going to change in our lifetimes but the science is kind of cool!



Comments

Gerhard Adam
...the dopamine inducing result but don't explain the underlying brain
deficits these poor folks are born with that causes the behavior.

Sorry, but that is simply overstating the case. 
But this genetic predisposition does not mean drug abuse is inevitable, Volkow said. Environment must be factored into the mix.

Dopamine receptor changes in these monkeys were not genetic, Volkow said, but instead were determined by environment.
http://www.mc.vanderbilt.edu/reporter/index.html?ID=2583

While there is no doubt that too much or too little dopamine has profound repercussions on the individual, it is not true addictions are inevitable because of such imbalances.  In fact, the argument is that by taking external drugs and raising the dopamine levels, we have paved the way for addiction, however this would be an after-the-fact event.  In short, by modifying our own brain chemistry we have elicited the behavior.

In fact, reading through the various symptoms surrounding low levels and high levels of dopamine offers a pretty clear indication that it would be highly unusual for someone to have such a tendency (whatever that even is) and be asymptomatic.
http://www.womensaccounts.com/mental_health_Carver_neurotrasmitter.html

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