Being obese can increase the risk of Alzheimer’s Disease by as much as 80 percent, according to a study in the May issue of Obesity Reviews. But it's not just weight gain that poses a risk. People who are underweight also have an elevated risk of dementia, unlike people who are normal weight or overweight.

US researchers carried out a detailed review of 10 international studies published since 1995, covering just over 37,000 people, including 2,534 with various forms of dementia. Subjects were aged between 40 and 80 years when the studies started, with follow-up periods ranging from three to 36 years.

The review, which included studies from the USA, France, Finland, Sweden and Japan, also included a sophisticated meta-analysis of seven of the studies, published between 2003 and 2007 with a follow-up period of at least five years.

Children who speak a second or third language may have an unexpected advantage later in life, a new Tel Aviv University study has found. Knowing and speaking many languages may protect the brain against the effects of aging.

Dr. Gitit Kavé, a clinical neuro-psychologist from the Herczeg Institute on Aging at Tel Aviv University, together with her colleagues Nitza Eyal, Aviva Shorek, and Jiska Cohen-Manfield, discovered recently that senior citizens who speak more languages test for better cognitive functioning. The results of her study were published in the journal Psychology and Aging.

However, Kavé says that one should approach these findings with caution. “There is no sure-fire recipe for avoiding the pitfalls of mental aging. But using a second or third language may help prolong the good years,” she advises.

Gestational age has long been the factor most commonly used to predict whether an extremely low-birth-weight infant survives and thrives, but four additional factors that can help predict a preemie’s outcome have been identified by the National Institutes of Health Neonatal Research Network.

Birth weight, gender, whether the baby is a twin and whether the mother was given antenatal steroid mediation to aid the baby’s lung development are all factors that affect survivability and risk of disability, according to an article in the New England Journal of Medicine by a consortium of researchers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. The 19-center network includes Yale School of Medicine and Yale-New Haven Hospital.

It's been thought that very preterm babies were not developed enough to benefit from 'comfort strategies but research published today in BMC Pediatrics suggests that even babies born between 28 and 31 weeks could benefit from skin-to-skin cuddling with their mother before and during painful procedures, such as a heel lance.

Celeste Johnston of McGill University, Montreal, Canada and colleagues have already shown that skin-to-skin contact, known as kangaroo mother care (KMC) helps babies born at 32 to 36 weeks to recover from pain.

New research by the Universities of Exeter and Oxford states that a child’s sex is associated with the mother’s diet. Their evidence shows a link between higher energy intake around the time of conception and the birth of sons. The findings may help explain the falling birth-rate of boys in industrialized countries, including the UK and US.

The study focused on 740 first-time pregnant mothers in the UK, who did not know the sex of their fetus. They were asked to provide records of their eating habits before and during the early stages of pregnancy. They were then split into three groups according to the number of calories consumed per day around the time they conceived. 56% of the women in the group with the highest energy intake at conception had sons, compared with 45% in the lowest group.

As well as consuming more calories, women who had sons were more likely to have eaten a higher quantity and wider range of nutrients, including potassium, calcium and vitamins C, E and B12. There was also a strong correlation between women eating breakfast cereals and producing sons.

People affected by Huntington’s disease, which affects up to one person in every 10,000 but clusters in families and certain populations, develop clusters of a defective protein in their neurons and shrinkage of brain areas associated with movement. The disorder causes disability and eventually death, but does not normally manifest until after people have had children, allowing the disease gene to be passed on.

“Although Huntington’s disease is considered the epitome of genetic determinism, environmental factors are increasingly recognised to influence the disease progress”, the researchers write.

Researchers in a large, multi-institutional study have found one gene variant that is linked to an increased risk of lung cancer.

The research team collected DNA from 1,154 smokers who have lung cancer and 1,137 smokers without lung cancer. Each DNA sample was analyzed at more than 300,000 points, looking for variations—known as single nucleotide polymorphisms, or SNPs for short—between those with cancer and those without. They then analyzed the top 10 SNPs in an additional 5,075 DNA samples from smokers with and without lung cancer.

Two of the 10 SNPs were consistently associated with lung cancer risk and both of them are located in chromosome 15 inside a region that contains genes for the nicotinic acetylcholine receptor alpha subunits 3 and 5, which already are suspected to play a role in lung cancer progression.

Everyone experiences anxiety from time to time – something specific, like going down into a dark cellar where you know the Book of the Dead is waiting,or, in a more general sense, trepidation about what the future holds. Some people are gripped by powerful fears when confronted by quite normal everyday situations. For example, sufferers of agoraphobia frequently have panic attacks when caught up in a crowd.

Their blood 'curdles' or 'freezes in their veins' in a very real way, saya a Bonn-based research team, and it leads to increased risk of thrombosis or heart attack

The symptoms can be dramatic: palpitations, sweating, shaking, blind panic or fainting – even leading to death. Another anxiety disorder frequently encountered can be described as social phobia. Those affected fear above all situations in which they become the centre of attention in a group. They begin to stutter or turn red. In order not to avoid embarrassment, social phobia sufferers may become recluses, shying away from human contact and staying at home.

Writing in the Journal of the American Medical Association, a medical team from the University of Leicester say they have established a predictor for pregnant women who may have miscarriages and those who won’t.

The researchers measured the levels of a naturally occurring ‘cannabis’ (an endocannabinoid) known as anandamide in women who presented with a threatened miscarriage (bleeding in early pregnancy with a viable baby) and found that those who at the time of the test had significantly higher levels of anandamide subsequently miscarried.

Researchers at Johns Hopkins have discovered that two clinically different inherited syndromes are in fact variations of the same disorder. The team suggests that at least for this class of disorders, the total number and “strength” of genetic alterations an individual carries throughout the genome can generate a range of symptoms wide enough to appear like different conditions.

“We’re finally beginning to blur the boundaries encompassing some of these diseases by showing that they share the same molecular underpinnings,” says Nicholas Katsanis, Ph.D., an associate professor of ophthalmology at the McKusick-Nathans Institute of Genetic Medicine at Hopkins. “This is important progress for several reasons. First, knowing what’s going on molecularly and being able to integrate rarer conditions under common mechanisms allows us to potentially help more people at once. Second, clinicians can finally begin to offer more accurate diagnoses based on what really matters: the state of affairs at the cellular/biochemical level. In time, this will empower genetic counseling and much improved patient management.”