Calcium is crucial for heart regeneration by cardiac stem cells following cardiovascular problems say scientists in an article to be published in the journal Circulation Research this 9th of October. The study also identifies the body molecules controlling calcium levels in the stem cells and reveals, how their manipulation, can lead to the formation of new cardiac tissue. The work, that follows the recent surprising discovery of stem cells within the heart, can have important implications in the regenerative medicine of this organ in patients with cardiovascular diseases.

What a difference a bulb makes? On the 6^th of November the 2100 inhabitants of the Isles of Scilly - a small British archipelago just off the mainland – will be asking this and a little more, by switching off for 24 hours all unused electrical apparatus, while measuring online, and in real time, the energy saved. This unique event aims to raise awareness of climate change and energy wastage, whilst showing how easy it is to make a real difference. All this is part of the “Isle of Scilly Earth Summit” that launches this weekend (3/4 October) with talks by islanders from all over the world followed by the energy saving day (E-Day) on the 6^th of October.

A new gene called AP2gamma has been discovered to be crucial for the neural development of the visual cortex in a discovery that can have implications for the therapeutics of neural regeneration as well as provide new clues about how the brain evolved into higher sophistication in mammals. The article will come out in the journal Nature Neuroscience¹ on the 14^th of September.

A new paradigm in the way we look at cancer with important implications on how we treat it is about to be published in the British Journal of Cancer by Portuguese, Belgian and American researchers. The group use a mathematical approach to reveal how - by changing the dynamics of interaction between the cancer cells and those of the affected tissue – it is possible to control and even potentially cure the disease.

Schistosoma haematobium (S. haematobium) is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer although why is not clear.

Two works by Portuguese researchers just out in The Journal of Experimental Pathology (1) and the International Journal of Parasitology (2) reveal that cells infected in laboratory with S. haematobium, acquire cancer-like characteristics and, when injected into mice develop into tumours. The research identifies as well the host molecules linked to the carcinogenic changes, suggesting that these could be used as therapeutic targets to prevent bladder cancer.

Every day we make a multitude of decisions based on the consequences of our actions; goal-orientated responses.

In an always changing environment this capacity is crucial but, because it is complex, it also requires a lot from the brain. So repeated actions, like to press the elevator button to our floor, become linked to other type of neural responses, which are automatic and so less demanding. And if necessary it is always possible to switch back to the first kind of response.

A gene called Chd1 has been identified in a Nature study as crucial for embryonic stem cell pluripotency - the ability to differentiate into any type of cell.  Chd1 seems to act by keeping the genetic material open and there poised to express any gene. Chd1 is also shown to be fundamental when reactivating differentiated tissue cells in order to create new stem cells.

The discovery has implications, not only for a better understanding of stem cells unique characteristics, but also for the process of obtaining them from tissue-specific cells avoiding all the problems associated with embryonic stem cells.

Scientists have discovered the gene behind Recessive Omodysplasia, a rare skeletal disease characterised by short-limbed dwarfism and craniofacial anomalies. The work, just published in the American Journal of Human Genetics, reports the identification on chromosome 13 of a gene - GPC6 – that is shown to be crucial for normal bone development.

The research will allow a better comprehension, as well as prevention, of the disease by permitting the screening of potential mutation carriers in pregnancy but most importantly will also help to understand better bone development and its molecular bases.

Scientists in Portugal and France managed to follow the patterns of gene expression in food-poisoning bacteria Listeria monocytogenes (L. monocytogenes) live during infection for the first time. The work about to be published in PLoS Pathogens shows how the bacterial genome shifts to better adapt to infection by activating genes involved in virulence and subversion of the host defences, as well as adaptation to the host conditions.

Helicobacter pylori (H. pylori) infection is considered one of the most important risk factors for stomach (or gastric) cancer with as much as 65% of all cases linked back to the bacteria, although exactly how this occurs is not fully clear.