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By Michael White | June 4th 2009 05:01 PM | 4 comments | Print | E-mail | Track Comments
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About Michael White

Welcome to Adaptive Complexity, where I write about genomics, systems biology, evolution, and the connection between science and literature, government, and society.

I'm a biochemist


... Full Bio

This can't all be good stuff: a paper I'm reading noted that "Just a few keywords (linkage, mapping,
SNP, genomewide association) identified 6866 articles in the PubMed database published in 2007 alone."

(Before you get too depressed, note that this means the total of each single keyword search, not a search for all 4 terms at once.)

Just for kicks, I tried my field. On Pubmed, there are 3664 papers published in 2009 alone that come up when I search for the term "cell cycle" (using quotes so that the search is for both words used together). If I limit my search to "cell cycle" and yeast, there are 242 papers from 2009. If I search for "transcription factors" and "yeast", there are 174 papers from 2009. "Cell cycle" and "transcription" brings up 699 papers.

A search for "systems biology" brings up 83 2009 review papers alone, and 744 total papers in 2009.

Trying other fields: a search for "genome-wide association study" turns up 388 hits from 2009. Searching for "human", "genome", "selection" brings up 308 papers from 2009.

The lesson here is that there is no time to waste reading lousy or irrelevant papers; just filtering things out properly takes a big chunk of time. You just have to be ruthlessly selective.




Comments

Hank's picture
Would this not be evidence that science is getting too much government funding?   If you practically need an assistant to weed out the redundant and likely unnecessary studies, why fund them with public money? 20 a month just in your specific field seems like a lot.

adaptivecomplexity's picture
That's a good question, basically related to the question, what is the optimal size of the academic science community? Keep in mind that part of this growth is because other countries have significantly increased their science funding, so more of these papers are being contributed by countries that previously did not contribute on the scale of the US, UK, Japan, and few continental European nations.
I'm of two minds on this: on the one hand, there is a LOT of good research left to be done out there, and you could have a significantly larger scientific community still doing productive research - which means that we just have to resign ourselves to the fact that nature is huge, and it's a lot of work just to keep up with a tiny corner.

On the other hand, many journals aren't selective enough, and a lot of useless stuff gets published. The NIH is more selective than most journals (although I don't know what the optimal acceptance rate for a journal should be) - in any given grant application cycle, 7%-20% of the applications typically get funded, and a large number just get triaged because (in most cases) they've got major deficiencies. So the government is being fairly selective.


It would be helpful to have more numbers - are individual labs publishing more, on average, or are there simply more labs publishing. For the bests labs, costs are probably going up, because the latest technology is expensive (although again, it would be great to see some numbers), and today's genomics research is much more reliant on 3rd-party technology than cutting-edge molecular biology was 20-30 years ago.

So I don't know.


jtwitten's picture
Trying other fields: a search for "genome-wide association study" turns up 388 hits from 2009.

How many were in Nature Genetics?

adaptivecomplexity's picture
I didn't count, but my educated, off-the-cuff guess would be... 90%. 
OK, maybe not, but they're in love with GWAS.



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